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Self-administered cocaine than for rats that passively received cocaine on a yoked schedule. It is difficult to choose among possible explanations for an enhancement of dopamine by response contingency, but the effect suggests that dopamine overflow is influenced by more than the pharmacological properties of cocaine itself. Finally, Bassareo and Di Chiara w14x found that a conditioned stimulus that predicted a palatable food elicited an anticipatory dopamine response in the prefrontal cortex but not in the nucleus accumbens. These negative microdialysis results Zalso Wilson et al. w493x. are difficult to interpret. One major problem in making strong inferences from negative microdialysis results concerns the inherent insensitivity of the microdialysis method for detecting small transient events in vivo w279, 342x Zof the sort to be expected in response to a conditioned stimulus. Lu et al. w279x and Peters and Michael w342x have provided a powerful illustration of these limitations. Negative results must be considered, therefore, in light of the positive results from the voltammetric and electrophysiological studies reviewed above. It remains unclear what experimental factors determine a positive vs. negative outcome. In conclusion, although the literature remains a little mixed, there is ample evidence to support the contention that mesolimbic and mesostriatal dopamine systems often are activated in advance by conditioned stimuli for hedonic incentives. 2.1.3. Anticipatory dopamine actiation: multiple interpretations Anticipatory responses by dopamine neurons to conditioned incentive stimuli have provided the grounds for various `reward learning' hypotheses of dopamine function. These anticipatory dopamine responses have often been interpreted to reflect a form of `neural expectation', a prediction of subsequent reward value, a correlational error detector, a teaching signal, or similar component of an associative mechanism that is dedicated to learning about rewards w3, 4, 23, 24, x. However, anticipatory responses to salient stimuli that have alerting, arousing and attention-grabbing properties are equally compatible with the incentive salience hypothesis. If the conditioned stimulus itself is attractive to the animal, and serves as a conditioned reinforcer, then it has acquired incentive salience of its own. The difference between the two views is that a learning hypothesis posits that dopamine neurons mediate associatie learning and expectations based on preious experience with a stimulus. It ascribes conditioned dopamine activity chiefly to the predictie value of the conditioned stimulus: what has been in the past is predicted for the future. The incentive salience hypothesis, by contrast, ascribes conditioned dopamine activity to its incentie value: whether it is `wanted'. This difference will be elaborated below. But even the hedonia hypothesis of dopamine function could be reconciled with anticipatory neural activity if one and loratadine.
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