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Resveratrol 3, 5, 4'-trihydroxy-trans-stilbene ; , an ingredient of wine, shows a broad spectrum of cytotoxic effects against human cancer cells. In order to enhance these effects, we introduced additional hydroxyl moieties into the molecule. The most potent resveratrol compound was 3, 3', 4, M8 ; which exerts a 1600-fold higher rate of cyclooxygenase II inhibition IC50: 0.00104 M and 1.67 M ; and a more than 6600-fold higher antiradical activity than resveratrol. Furthermore, M8 also exhibited a threefold higher cytostatic activity in HL-60 leukemic cells compared to resveratrol 4.2 + 0.09 M and 12.1 + 0.17 M ; . In HL-60 cells, M8 depleted the deoxynucleoside triphosphates dATP and dTTP pools to 41% and 21% of control values, whereas dCTP pools increased to 199% of untreated controls. In addition, TTP, ATP, CTP, and GTP concentrations were decreased while UTP concentrations increased. M8 induced apoptosis at concentrations significantly lower than resveratrol and could remarkably inhibit the activation of NF- B. M8 arrested cells in the S phase of the cell cycle while depleting cells in the G2-M-phase. Besides leukemia cells, M8 also demonstrated a more than four-fold higher anti-proliferative effect against human 518A2 melanoma cells. Single agent treatment by M8 significantly reduced the growth of 518A2 xenografts when administered i.p. daily at doses of 2.5 or 5 mg kg d. Moreover, if combined with the standard melanoma chemotherapeutic dacarbacine, M8 cotreatment led to eradication of melanoma xenografts in 50% of SCID mice. Due to these promising results, the novel resveratrol analogue M8 might serve as a drug candidate for the treatment of leukemia and malignant melanoma, because lexapro escitalopram oxalate. 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